الفهرس | Only 14 pages are availabe for public view |
Abstract Immune thrombocytopenia (ITP) is a known autoimmune disorder characterized by a low platelet count (below 100 x109/L) and the absence of obvious initiating and/or under lying cause of thrombocytopenia. It is caused by destruction of antibody-sensitized platelets in the reticuloendothelial system and impaired production of platelets in the bone marrow). Vitamin D is recognized as a true steroid hormone that exerts several biological activities, including regulation of the immune system . Its deficiency can contribute to the pathophysiological mechanisms for the development many of autoimmune diseases. The incidence and severity of certain autoimmune diseases are associated with Vitamin D receptor polymorphisms . The mechanism by which VDR polymorphism affects autoimmunity is still unclear, although activation of the receptor attributes to immune responses through regulation of the T-helper (Th)1/Th2 cytokine balance and decreases production of Th2 cytokines. The aim of the study was to highlight the association of VDR gene polymorphism BsmI in childhood chronic ITP and compare gene and allele frequency in patients and controls in terms of VDR polymorphisms aiming at opening the scope for new targeted therapy for patients with chronic ITP. Our study was case-control study including two groups. The patient group included 50 child with chronic ITP in addition to 50 healthy controls of matched age, sex and socio-economic state. |