Dedication
List of contents
List of abbreviations
List of tables
List of figures
Introduction
Aim of the work
Review of Literature
Mucosal-associated invariant T (MAIT) cells
Antigens detected by MAIT cells
Tools for studying MAIT cells
MAIT cell development
MAIT cell activation and effector function
MAIT cell subsets
Systemic lupus erthymatosus (SLE)
Etiology/pathophysiology
Diagnosis of SLE
Immunopathogenesis in SLE
Environmental risk factors
Genes and gene expression
Apoptosis and nucleic acid sensors
Soluble mediators
Some cell types involved in SLE
MAIT cells in SLE
Patients and methods
Subjects
Materials and Methods
Results
Demographic, clinical, and laboratory characteristics of patients with SLE
Levels of mucosal-associated invariant T (MAIT) cells, MAIT cell subsets, and HLA-DR+ MAIT cells in SLE patients and healthy controls
Comparison of interferon gamma-induced protein 10 (IP-10) between patients and controls and its relation with disease activity
Levels of MAIT cells and HLA-DR+ MAIT cells in SLE patients according to the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI)
Levels of MAIT cells and HLA-DR+ MAIT cells in SLE patients in relation to lupus nephritis
Correlations of MAIT cells and HLA-DR+ MAIT cells with the different clinical and laboratory findings in SLE patients
Correlations among MAIT cells and HLA-DR+ MAIT cells
Discussion
Summary
Conclusion
Recommendations
References
Arabic Summary
الملخص العربي