الفهرس 
Surgical Anatomy of Thyroid GlandOnly 14 pages are availabe for public view
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Abstract
Objectives: We are trying to evaluate both ultrasound criteria (based on TI-RADS classification} and FNAC in the assessment of suspicious thyroid nodules by analyzing their results with final histopathology outcome after thyroidectomy to detect their sensitivity and specificity in the differentiation of benign and malignant thyroid nodules.
Methods: This is a prospective randomized clinical trial study conducted in Ain Shams University Hospitals in Egypt from December 2018 until December 2020.The study included 50 patients suffering from suspicious thyroid Nodules either single or multiple nodules .Patients underwent ultrasound based on TI-RADS system and FNAC then, all patients underwent either total or hemi-thyroidectomy operation. Specimens sent for histopathological examination which is considered as gold standard. The results of TI-RADS and FNAC (based on Bethesda categories) were compared with the final histopathology outcome.
Results: The accuracy, sensitivity, specificity, positive predictive and negative predictive value of FNAC were 80%, 77.8%, 98%, 90%, and 88.2% and TIRADS were 75%, 88%, 92%, 81%, and 76.6%, respectively. FNAC was less sensitive but more specific than TIRADS. Our study found that the overall comptability between TI-RADS and FNAC is 67% in diagnosis of suspicious thyroid nodules (82.6% in benign cases, 68.4% in indeterminate cases 50% in malignant cases).
Conclusion: TI-RADS is more sensitive in diagnosing suspicious thyroid nodules but FNAC is more specific, FNAC is a minimally invasive method which can be used to distinguish malignant from benign lesions with a high degree of accuracy (80%), both TI-RADS and FNAC systems are effective diagnostic modalities for predicting malignant lesions in patients having suspicious thyroid nodules.