الفهرس 
ACKNOWLEDGMENTOnly 14 pages are availabe for public view
 |  | from | 130 |  |  |
| | | from | 130 | | |
Abstract
The current study was conducted at women’s health hospital, Assiut University Hospitals between March 2018 and June 2020 and included 80 parturients (20-40 years, ASA I-II), scheduled for elective cesarean section (CS) under intrathecal anesthesia.
Parturients were randomly allocated into 2 equal groups. Intrathecal block was performed at the level of L 3-4 or L 4-5 intervertebral disc spaces; 12.5 mg (2.5 mL) of hyperbaric bupivacaine 0.5% and 200 ug morphine sulphate was injected intrathecally. The study drugs were given 30 min before administration of intrathecal anesthesia. group (A) received 2 mL of normal saline 0.9% IV and group (B) received 2 mL of 2 mg granisetron IV injection. Two blood samples (2 mL each) for serum serotonin measurement were withdrawn from each parturient. One sample was withdrawn in the holding area before preload infusion and granisetron injection and the other one was withdrawn 6 hours after intrathecal morphine injection in both groups.
The onset of pruritus using pruritus grading system was assessed and recorded at 1, 2, 3, 4, 6, 12, 18 and 24 hours post-surgery. For patients with pruritus who request treatment, antihistamines such as pheniramine maleate and μ-opioid receptor antagonists such as naloxone were used depending on the severity assessed by the clinician, if required.
Postoperative pain using VAS, perioperative adverse events and participants’ satisfaction after end of surgery were recorded.
RESULTS:
There was no statistically significant difference (P-value <0.05) between the two study groups regarding the age, height, weight, and the duration of surgery.