الفهرس | Only 14 pages are availabe for public view |
Abstract Behçet’s disease (BD) is a chronic multisystemic inflammatory disease characterized by recurrent oral and genital ulcers, skin lesions, and uveitis. It also affects all types and sizes of blood vessels, the joints, central nervous system, lungs, and gastrointestinal system. Although its etiology is unclear, neutrophil hyperfunction, vasculitis, and autoimmune and inflammatory responses are its major pathological features. Neutrophils, lymphocytes, and platelets play a role in the control of inflammation, and systemic inflammation is associated with alterations in the quantity and composition of circulating blood cells, such as neutrophilia, lymphopenia, and thrombocytosis. Mean platelet volume (MPV), neutrophil‐to‐lymphocyte ratio (NLR), and platelet‐to‐lymphocyte ratio (PLR) have recently been investigated as new inflammatory markers in many inflammatory, cardiovascular, and malignant diseases. This study aimed to asses disease activity in relation with blood parameters. The study included 36 Behçet’s patients, 36 healthy people as control. In this study, we measured disease activity of both groups using using the simplified Behçet’s Disease Current Activity Form, Clinical and laboratory assessments. Also we measured NLR, LMR, MPV &PLR from complete blood count from both study patients. And ESR, CRP This study found that NLR increased in Behçet disease in relation to control (p= 0.008) and increase in active Behçet patients in relation to in active (p= 0.009) and also increase in high activity than in low activity (p < 0.001). Also this study found that PLR increased in Behçet disease in relation to control (p= 0.011) and increase in active Behçet patients in relation to in active (p= 0.047) and also increase in high activity than in low activity (p =0.027). |