الفهرس | Only 14 pages are availabe for public view |
Abstract • Introduction: subclinical hypothyroidism ( SCH ) is defined as an increased serum TSH above its upper limit of reference range with a normal free T4 level .. in recent years , a high prevalence of correlation between rheumatic diseases and autoimmune thyroid diseases was demonstrated emphasizing the like hood of a common pathogenic basis among them Although, there were a lot of researches discussed such association , till now, the possibility of thyroid dysfunction in patients with rheumatic diseases has not been well defined • Aim of the work: The aim of our study was to assess prevalence of subclinical hypothyroidism in patients with rheumatological diseases • Subjects and methods: The study was cross sectional observational study conducted on total of 180 patients selected from patients who were attending to the Rheumatology and Immunology unit, internal medicine department and 10 matched age and sex controls during the period from February 2020 to February 2021.. all selected patients were subjected to history taking and physical examination. blood samples were collected for thyroid function test ( TSH and FREE T4 ), lipid profile • Results : SCH was reported in 6.7 % of the studied cases, fatigue was recorded in 27.2% of the studied cases , 5.6 % of cases developed high total cholesterol, 5.6 % of cases developed high LDL- C and only 2.8% developed high TGS ,, fatigue was demonstrated to be significantly increased among cases with subclinical hypothyroidism compared to those without subclinical hypothyroidism • Conclusion: it was concluded that, rheumatic diseases were demonstrated to be associated with a considerable degree of SCH development, in addition, fatigue as well as dyslipidemia increased among SCH affected cases compared to those without SCH and have demonstrated significant improvement following initiation of throid replacement therapy. |