الفهرس | يوجد فقط 14 صفحة متاحة للعرض العام |
المستخلص Nephrotic syndrome is one of the most important kidney diseases in paediatric age group. It cause leakage of several proteins in urine such as certain coagulation factors and antithrombin III. Objective: To predict the possible risk of thromboembolic complication development in children with nephrotic syndrome due to antithrombin III deficiency and to compare between serum levels of antithrombin III in patients with nephrotic syndrome during both relapsing and after 6 weeks of the start of steroid treatment. Patients and Methods: This study was cross sectional study conducted in outpatient Nephrology Clinic of Children's Hospital, Fayoum University started from January 2016 to December 2016. It included 27 children with nephrotic syndrome to be followed during both relapse and after 6 weeks after start of steroid therapy, and 27 healthy children as control group. 1 Results: There were significant decreases in antithrombin III, albumin and total proteins levels in the study group during relapse but after steroid therapy their levels were improved while there were significant increases in platelet count, cholesterol, triglycerides levels during relapse which also improved after steroid therapy. There was no thromboembolic complications detected among the study group. Conclusions: antithrombin III level was significantly decrease in children with nephrotic syndrome and despite of the hypercoagulable state no thromboembolic complications can be detected in children with nephrotic syndrome. Keywords: Nephrotic syndrome - Antithrombin III - Steroid therapy - Hypercoagulable state - Thromboembolic complications. |