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Abstract The diagnosis of acute catarrhal appendicitis is primarily clinical and should be made on clinical symptoms and signs. However, some patients have equivocal physical findings and may be admitted for a period of observation. We suggest that these patients could also have serial TLC count and CRP test taken as an aid for diagnosis. The aim of study is to evaluate the outcome of single prophylactic dose of antibiotic in patients with Catarrhal appendicitis regarding post-operative wound infection. This study included 60 patients with a suspected diagnosis of acute non-complicated appendicitis divided into two groups: group (A): Includes patients with the single prophylactic dose of antibiotic (third generation of cephalosporin + metronidazole). group (B): Includes patients on concurrent regimen of antibiotic therapy (pre-operative induction dose + post-operative injection & oral antibiotic therapy). Our study demonstrated group (A) consists of 18 males (60 %) and 12 females (40 %). While group (B) consists 20 males (66.7%) and 10 females (33.3%). No significant difference was found between two groups p-value (0.59). As regard age: group (A) age ranged from 7 to 34 years old with mean value 20.5 years old while in group (B) ranged from 9 to 35 years with mean value 22 years old. There was no significant difference between two groups p-value 0.08. As regard the duration of pain: in group A: ranged from 11 to 48 hours with a median of 29.5 hours while in group B: ranged from 6 to 40 hours with a median of 23 hours. There was significant difference between two groups p-value 0.04. As regard preoperative TLC count and CRP test: group (A): TLC count ranged from 5400-13000 with mean value 9200 while in group (B): TLC count ranged from 4800-12800 with mean value 8800. There was no significant difference between two groups p-value 0.466. group (A): CRP test was +ve in 21 patients & -ve in 9 patients while in group (B): CRP test was +ve in 17 patients & -ve in 13 patients. There was no significant difference between two groups p-value 0.29. As regard postoperative wound infection, in group (A) only 3 patients had postoperative wound infection (10.0%) while in group (B) 2 patients had postoperative wound infection (6.65%). There was no significant difference between two groups p-value 1.0. |