الفهرس 
Acute Kidney InjuryOnly 14 pages are availabe for public view
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Abstract
Background: Extracorporeal shock wave lithotripsy (ESWL) was introduced more than three decades as an authentic modern modality for the treatment of urinary stone disease. It is considered first choice of treatment for nearly all kinds of urinary tract calculi.
Objective: To evaluate the damage effect of ESWL on kidney tissue by measuring non-coding lnc-RNA profile in serum before and after ESWL session and assess their usefulness as diagnostic biomarkers for AKI and the relationship between the selected RNA based biomarker panel and clinicopathological changes of patients.
Patients and Methods: It is a prospective randomized control study assessing the damage effect of ESWL on kidney tissue by measuring non-coding lnc-RNA profile in serum before and after ESWL session(s) in 20 patients and compare it to control group of 20 healthy persons with no known urogenital disease and no known history of urologic pathology.
Results: The results favored outcomes of pre procedure lncRNA showed a statistically significant reduction after 48 hours after the procedure (p =0.017). In comparison with control group the lncRNA showed a statistically significant difference between patients and controls at 2 hours and 48 hours after the procedure (p =0.03 and 0.01, respectively).
Conclusion: Although ESWL is considered a safe and effective procedure in the treatment of renal stone disease yet it may cause acute renal injury. In this study, serum lncRNA rises significantly following acute renal injury caused by ESWL. Hence, serum lncRNA together with other kidney function tests as serum urea, creatinine can be used as acute renal injury markers following ESWL in patients with renal stone disease.