Search In this Thesis
   Search In this Thesis  
العنوان
Lap. Versus open complete mesocolic excision for colon cancer. A randomized controlled trial /
المؤلف
Hussein, Mohammed Moustafa.
هيئة الاعداد
باحث / محمد مصطفي حسين سليمان
مشرف / مرسي محمد مرسي
مناقش / محمد قرني عويس
مناقش / جمال عبد الحميد احمد
الموضوع
Colon Cancer.
تاريخ النشر
2021.
عدد الصفحات
120 p. ;
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
جراحة
الناشر
تاريخ الإجازة
8/2/2021
مكان الإجازة
جامعة أسيوط - كلية الطب - general surgery
الفهرس
Only 14 pages are availabe for public view

from 150

from 150

Abstract

Since its first introduction in 1991, laparoscopic colorectal surgery for colorectal cancer has increased rapidly, based on its particular benefits, including minimal trauma, decreased postoperative pain, earlier ambulation, faster recovery, and shortened hospital stay. Complete mesocolic excision (CME) is consistent with the concepts of total mesorectal excision (TME) and has good surgical and oncological outcomes. However, reports regarding laparoscopic CME are fewer than those regarding laparoscopic rectal cancer. The aim of this study is to assess pathological, oncological and surgical outcomes of CME of colon cancer by open and laparoscopic surgery. This work was conducted on 35 patients of different sex and age groups suffering from different stages of colon cancer treated by laparoscopic and open techniques, 20 males and 15 females. We excluded metastatic cases, complicated cases, peritoneal seeding and malignancy in the previous 5 years. As regard to the tumor location, we found that 14 cases (7 LAP vs 7 Open) belonged to the Right colon and 9 cases (5 vs 4) belonged to the Left colon and 9 cases (4 vs 5) belonged to the Sigmoid colon and 3 cases belong to the transverse colon (2 vs 1). As regard to the short-term surgical outcomes, the operative time was longer in the LAP group and intraoperative blood loss was less in the LAP group. The rate of conversion in LAP group was 11.8% and occurred in 2 cases due to uncontrolled bleeding. Postoperative GIT recovery was better in the LAP group and postoperative hospital stay was shorter (7 days vs 8.89 days). Post-operative pain was less in the LAP group compared to the Open one. Postoperative 30-day complications occurred in 9 patients (2
LAP vs 7 Open), Anastomotic leakage in 3 patients (1 vs 2), pneumonia in 2 patients (1 vs 1), ileus in 1 patient in the Open group, sexual dysfunction in 1 patient in the Open group and wound infection in 2 patients in the Open group. As regard to the long-term surgical outcomes, Adhesive intestinal obstruction occurred in one patient belong to Open group. Incisional hernia occurred in 4 patients (1 LAP vs 3 Open). As regard to the pathological outcomes, there were no significant differences between the two groups as regard mean number of retrieved LNs (27 vs 29), distance from the tumor to the high arterial tie, circumferential resection margin and mesocolon grade. As regard to the oncological outcomes, Recurrence occurred in 5 cases (3 LAP vs 2 Open). Local recurrence occurred in 1 case of the LAP group, liver metastases occurred in 5 cases (3 vs 2) and lung metastases occurred in 2 cases (1 for each group). Through 2 year follow up period, 4 patients died (2 patients for each group). The mean overall survival duration (23.44 LAP vs. 23.29 Open (month). Both groups have equivalent recurrence and overall survival rate. To conclude, laparoscopic CME is feasible, safe with better postoperative convalescence and similar oncological outcomes to conventional CME. However, large number of cases and long duration of follow up are needed to assess survival and oncological outcomes.