الفهرس | Only 14 pages are availabe for public view |
Abstract Degenerative diseases of the nervous system impose substantial medical and public health burdens on populations throughout the world. Alzheimer’s disease (AD), Parkinson’s disease, and amyotrophic lateral sclerosis (ALS) are three of the major neurodegenerative diseases. The prevalence and incidence of these diseases rise dramatically with age. Monosodium glutamate (MSG) is a sodium salt of glutamic acid widely used as a flavor enhancer in the marinades of red meat, fish, chicken, vegetables, sauces, soups, and pre-packaged foods . Recently, it was reported that MSG specifically impairs the brain’s physical functions and causes oxidative damage, sudden neuronal death. The neurotoxic effects of MSG are related to acute degenerative changes and chronic neurodegenerative defects. Fluoxetine (FLU) was first approved as an antidepressant. Later on, improvements in cognition, memory, and mental processing speed have been reported after treatment with fluoxetine for neurodegenerative diseases. |