الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Hemangiomas are the most common tumors of infancy. hemangiomas occur in all races, but are more common in Caucasian infants than infants of African or Asian descent. The incidence of hemangiomas is 3 times higher in female infants than male infants. Although most infantile hemangiomas have uncomplicated clinical course and they undergo spontaneous involution. However, some hemangiomas may be complicated by ulceration, bleeding, airway obstruction; visual field obstruction in addition to the emotional and psychological distress to the child and parents, also the result of natural involution is not always cosmetically acceptable. Early intervention has been shown to reduce the need for corrective surgery after involution has occurred. Several treatment modalities have been employed in such cases to prevent or treat these complications including corticosteroids whether given orally or intralesional, laser photocoagulation and surgical excision. In 2008 after the discovery that hemangiomas regress in children treated with propranolol there has been a series of publications describing its therapeutic efficacy and side effects. The development of local treatments based on the dramatic efficacy of beta-blockers seems logical, and some physicians have published a positive experience with topical timolol. The purpose of this study is to evaluate the clinical efficacy and side-effects of oral Propranolol in comparison to topical Timolol for the treatment of hemangioma This prospective randomized study included 20 patients with cutaneous infantile hemangioma attended the Pediatric Surgery clinic at Menoufia Main University Hospital and Damanhour National Medical Institute. All patients were submitted to pretreatment workup including CBC, blood glucose, pulse and echocardiogram. Determination of the location and dimensions of hemangioma was done based on direct measurement and photographic analysis. Radiological assessment using doppler US as baseline data as regard: site and size of hemangioma was also done.