الفهرس 
Gastrointestinal tract cancers
CpG island methylator phenotype pathway:Only 14 pages are availabe for public view
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Abstract
Gastrointestinal (GIT) cancers represent the third common cancers worldwide, characterized by rapid progression and
higher mortality rate. Matrix metalloproteinases (MMPs) play an important role in cancer metastases. The present study
was conducted to estimate and evaluate the role of MMP-7, -9, -10 and -12 and TGF β1 along with conventional biomarkers
(CEA and CA19-9) in gastric (GC), pancreatic (PC) and colorectal cancer (CRC) staging system according to tumor size (T),
included lymph node (N) and metastasis (M). Seventy-five patients were divided into GC group (n = 25), PC group (n = 25),
CRC group (n = 25) and twenty-five healthy subjects (control group). Serum levels of MMP-7, -10 and -12 were assayed
simultaneously using luminex multiplex technique. Also, MMP-9, TGF-β1, CA19-9 and CEA were determined by ELISA.
MMP-7,-9,-10, -12, TGF-β1 and CEA levels were significantly (p < 0.001) higher in GIT cancer groups compared with
control. CA19-9 was significantly (p < 0.001) higher in PC and CRC groups compared with control. MMP-9 was positively
correlated with TNM staging in PC patients. MMP-12 was negatively correlated with T in PC and positively correlated with
M in CRC group. CA 19-9 was positively correlated with M grade in CRC. Depending on the estimated cutoff values of
area under receiver curve; CA19-9 and MMP-7 were excellent diagnostic markers in PC, CEA and MMP-7 were excellent
in CRC, and MMP-7 and MMP-9 were excellent in GC. Our findings indicated the clinical utility of MMPs in diagnosis and
TNM staging of GIT cancers along with CEA and CA19-9.