الفهرس 
Introduction And Aim of the workOnly 14 pages are availabe for public view
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Abstract
This study was conducted at the Otorhinolaryngology department in Minia University Hospital between February 2018 and February 2019. Forty patients of both sex, aged 6-75 years old, scheduled to undergo surgical excision of benign laryngeal lesions and histopathological examination to diagnose helicobacter pylori were enrolled in this prospective study.
The following were done to all patients: detailed medical history, general systemic examination, complete nasal and paranasal sinuses examination, examination of both ears and examination of the larynx by laryngoscopy. All patients were subjected to excisional biopsy from the laryngeal lesions by micro-laryngeal surgery under general anesthesia and biopsies were examined by histopathology to diagnose its nature and helicobacter pylori in it.
The aim of this study was to evaluate the correlation between helicobacter pylori infection and benign laryngeal lesions and its role as a risk factor in these lesions.
The following variables were recorded; age and sex of the patients, laryngopharyngeal reflux, helicobacter pylori stool antigen test and histopathological evaluation of the biopsies by hematoxylin and eosin stain to know the nature of the lesions and Giemsa stain to diagnose helicobacter pylori in the lesions.
The results of this study revealed that age of the patients was 6-75 years old with mean age 39.6±17.4 years old, 26 (65%) males and 14 (35%) females, 21 (52.5%) patients with laryngopharyngeal reflux, 15 (37.5%) patients with positive stool antigen test and 8 (20%) patients with positive histopathological examination by Giemsa stain.
There was also regarding the nature of the lesions 22 (55%) patients with vocal fold polyp, 8 (20%) with vocal fold cyst, 2 (5%) with vocal fold nodule, 4 (10%) with Reinke’s edema, 2 (5%) with leucoplekia and 2 (5%) with papilloma.
When we compared between positive and negative cases, there was no statistically significant difference between them according to age, sex of the patients and laryngopharyngeal reflux.
But there was statistically significant difference between positive and negative cases regarding the different types of laryngeal lesions with the majority of positive cases found in patients with vocal fold polyp and there was insignificant correlation between them.
There was also statistically significant difference between positive and negative cases as regard stool antigen test which showed significant agreement between them and there was statistically significant high sensitivity, specificity and accuracy of stool antigen test for diagnosis of helicobacter pylori.
CONCLUSION
We concluded that helicobacter pylori may be considered as a reliable cause and risk factor for benign laryngeal lesions especially vocal fold polyp. Our results also proved that stool antigen test could be used as a reliable test for diagnosis of helicobacter pylori such as histopathological examination by special stains with high sensitivity, specificity and accuracy of this test.