الفهرس | Only 14 pages are availabe for public view |
Abstract Large number of active compounds that shows high activity in vitro in treating various diseases especially cancer, very few candidates have shown clinical success. They do not have the ability to reach the target site of action. One of the approaches used to overcome this serious issue is the development of targeted drug delivery systems that release the drugs at the desired site of action. This could increase therapeutic efficacy of the drugs through improved pharmacokinetics and biodistribution and also decrease their side effects. Particularly, polysaccharides such as chitosan and its derivatives can be utilized in various medical applications, because of its biological properties and biodegradability. Moreover, chitosan and graphene oxide have various therapeutic properties such as inhibition of growth of microorganisms and others. In addition, silicon and iron oxides have also been proposed as good adsorbents and promising drug delivery systems, separately. Therefore, the specific aims of the work carried out in this thesis can be summarized as follows. |