الفهرس 
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Abstract
Background: Many experimental and clinical studies showed that
myoinositol has insulin-sensitizing effect in insulin resistance
conditions as typically seen in type 2 diabetes mellitus (T2DM).
Since there is a lack of evidence about the use of myoinositol in
T2DM.
Aim: Our study was conducted to assess the possible antidiabetic
and antihyperlipidemic effects of myoinositol, compare its effect
to those of metformin and evaluate if there are more beneficial
effects when using both drugs together in an animal model of
diabetes induced by high fat diet (HFD) / streptozotocin (STZ).
Methods and drugs: 50 male Wister rats were randomly divided
into 5 groups (10 per group), named as normal control group,
diabetic control group, myoinositol treated group, metformin
treated group and myoinositol+metformin treated group. After
induction of type 2 diabetes, all drugs were taken for 4 weeks by
gastric gavage.
Parameters measured: Body weight (BW), fasting blood glucose
level (FBG), fasting plasma insulin, homeostasis model
assessment of insulin resistance (HOMA-IR), glucose
disappearance rate (KITT%/minute) of insulin tolerance test, lipid
profile and glucose transporter 4 (GLUT4) expression.
Results: All treated groups showed non-significant change in BW,
significant reduction in FBG, significant reduction in plasma
insulin level, significant decrease in HOMA-IR and increase in
KITT %/minute, significant improvement of lipid profile and
significant increase in GLUT4 expression. The improvement of
insulin resistance, hyperglycemic state and hyperlipidemia were
better in combination therapy than in using either drug alone.
Abstract
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Conclusion: These findings suggest that myoinositol plays an
effective role in glucose disposal into skeletal muscles by
increasing GLUT4 expression that represents one of the most
common causes of insulin resistance; hence, it may be used in the
treatment of T2DM. In addition, combining myoinositol to
metformin is more effective than using either drug alone