الفهرس | Only 14 pages are availabe for public view |
Abstract Urolithiasis affects about 12% of the world population especially in western countries. There are multiple options for the treatment. Observational treatment is one option for treatment of lower ureteric stones. In a patient who has a newly diagnosed ureteral stone < 10 mm and whose symptoms are controlled, observation with periodic evaluation is an option. Patients may be offered an appropriate Medical Expulsive Therapy (MET) which modifies the ureteral motility to facilitate stone passage. In this study sample size was 130 patients where they calcified into two groups: group A: (65 patient) received Silodosin 8 mg controlled-release capsule once daily at constant time. group B: (65 patients) received Tamsulosin 0.4 mg capsule once daily at constant time. Patients of both groups are followed up for a period of 4 weeks for detection stone expulsion. Tamsulosin and silodosin are safe and effective treatment that enhance spontaneous passage of distal ureteric stones sized 10 mm or smaller. They appear to have near profiles in terms of expulsion rates and times, mean number of pain episodes and need for analgesics, but silodosin better in the treatment of lower ureteric stones than Tamsulosin in increasing rate of stone passage, reduction of time of stone passage. This study demonstrate a lower incidence of side effects related to peripheral vasodilation and an higher incidence of an ejaculation with silodosin thus making this drug mainly suitable for older patients. |