الفهرس 
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Abstract
There is a need for the development of new diagnostic tests that can detect the presence of active periodontal disease, predict future disease progression, and evaluate the response to periodontal therapy, thereby improving the clinical management of periodontal patients. Advances in diagnostic research in oral and periodontal diseases are moving toward methods whereby periodontal risk can be identified and quantified by objective measures (e.g., biomarkers) one such marker, CD40L which can be detected with CVD. Aim: To assess CD40L level in serum of chronic periodontitis patients with cardiovascular diseases. To determine the effect of non-surgical periodontal therapy on CD40L. Level in those patients. Subjects and Methods: Forty five subjects were included in the study. Fifteen subjects as chronic peiodontitis with CVD and fifteen subjects as CVD Patients and fifteen subjects as chronic peiodontitis as study groups. Full-mouth clinical periodontal parameters, including periodontal probing depth, plaque index, gingival index and gingival bleeding index) were recorded at baseline in all groups and after treatment in study groups. Serum sample was collected at baseline and four weeks after therapy for groups I&III and at baseline for the group II. Result: The results of the present study, showed a significant reduction in all clinical parameters (GI, PI, PPD, GBI and CAL) after treatment in group I&III. The CD40L were highly significantly reduced after treatment in groups I&III. Were versus of CD40L in groups high levels in CVD with chronic periodontitis versus groups II&III. At base line and after treatment both sides of study group was high significant in clinical parameter and levels CD40L. Conclusions: CD40L is elevated in chronic periodontitis patients as well as in CVD patients. CD40L level in serum has been found to decrease after phase 1 periodontal therapy. CD40L is a novel marker and has a role in mediating periodontal destruction and disease progression. The importance of maintaining periodontal health not only for achieving good oral health but also for a healthy systemic vascular status. Recommendations: CD40L could be used as a potential diagnostic marker for periodontal disease activity in serum. Elevated plasma levels of CD40L could be a risk factor for future CVD events. Further studies should be accomplished with greater number of patients to explain the etiological relationship between periodontal disease & CVD.