الفهرس | Only 14 pages are availabe for public view |
Abstract I nduction of labor is one of the most common interventions practiced in modern obstetrics. In the developed World, the ability to induce labor has contributed to the reduction in maternal and perinatal mortality and morbidity (ACOG, 2017). About 10 percent of pregnancies may be prolonged. In general, the longer the truly post-term fetus stays in the uterus, the greater the risk of a severely compromised fetus and newborn infant. Therefore, of major importance in handling compromised postdate pregnancies is the use of a suitable method of labor induction (Petraglia et al., 2003). During pregnancy, large amounts of CRH are released from the placenta and fetal membranes. An increment in plasma CRH concentration occurs during spontaneous labor, with peak value at vaginal delivery (Riley & Challis, 2003). The corticotrophin-releasing hormone (CRH), which has been identified in various organ systems, including the female reproductive system, is the principal regulator of the hypothalamic-pituitary-adrenal axis. Circulating placental CRH is responsible for the physiologic hypercortisolism of the latter half of pregnancy and plays a role in the onset of labor (Kalantaridou et al., 2007). The aim of this study was to determin the effect of intra muscular dexamethasone on the duration of latent phase duration induction of labor in primigravida past date peregnancey. This randomized controlled trial was conducted on 120 pregnant women whom are admitted for labor induction at Ain Shams University Maternity Hospital. The participants were randomly assigned by computer list into group I (Study group) N=60 and group II (Control group) N=60. group І: in which 60 participants received two doses of dexamethasone (8mg) intra-muscular at a prefilled syringe containing colorless solution with interval 12 hours. group II: in which other participants received placebo (distilled water). The study showed the following results: The study showed no significant differences between women of both groups regarding age, BMI. There were no significant differences between women of both groups regarding mode of delivery, rates for Cesarean delivery for intrapartum fetal compromise or failed progress of labor. The mean values for induction-to-active phase and total duration of labor were significantly lower among women of group I when compared to women of group II [MD (95% CI) -0.68 hours (-0.98 to -0.37), p<0.001 and -0.79 hours (-1.18 to -0.41), p<0.001]. There were no significant differences between women of both groups regarding birth weight, Apgar scores, rates of meconium-stained amniotic fluid, or rates of NICU admission. |