الفهرس 
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Abstract
The current study was carried out to evaluate the antiulcer properities of curcumin and capsicum extract after induction of peptic ulcer by piroxicam. The pharmacological activities of curcumin and capsicum extract were investigated by measurement of gastric volume, gastric juice decrease percentage, mean ulcer score, ulcer index and curative ratio as well as haematological, biochemical and histopathological examination. Experimental design: Forty five male Wister albino rats weighing 180-200 gm, were divided into five equal groups. The Results: 1. Body weight: Oral administration of piroxicam as a single oral dose revealed a significant decrease in final body weights.
2. Volume of gastric juice and gastric juice decrease percentage: Oral administration of piroxicam displayed a significant increase in volume of gastric juice. Administration of rantidine orally resulted in non-significant decrease in volume of gastric juice.
3. Macroscopic picture of lesion: While, treatment with rantidine revealed apparently normal gastric mucosa in all parts. Mild inflammatory reaction and or hyperemic capillaries were seen in the mucosa of some cases with mild infiltration of lymphocytes in the mucosa and mild infiltration of eosinophiles and lymphocytes in the submucosa.
4. Haematological findings: Administration of piroxicam as a single oral dose produced a significant decrease in RBCs count, Hb and PCV values when compared with control group. Treatment of peptic ulcer with rantidine, curcumin and capsicum extract showed a significant increase in RBCs count, Hb and PCV compared with piroxicam treated group. Administration of piroxicam as a single oral dose produced a significant decrease in MCV values. Treatment of peptic ulcer with rantidine, curcumin and capsicum extract showed a significant increase in MCV. Administration of piroxicam as a single oral dose revealed a non-significant increase in MCHC. Oral administration of piroxicam induced a significant increase in WBCs count.
5. Biochemical findings:
5.1. Antioxidant Enzymes activities.
5.2. Lipid Peroxidation (Malondialdehyde concentration) (MDA).
5.3. Proinfammatory cytokine (TNF-a).
6. Histopathological examination: Oral administration of piroxicam revealed erosive changes represented by superficial necrosis of the first layer of the mucosa with presence of desquamated cells in the gastric lumen, mild inflammatory reactions in the mucosa and submucosa beside congested mucosal blood vessels.