الفهرس 
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Abstract
Antibiotics or antibacterials are types of antimicrobials used in the treatment and prevention of bacterial infection. They may either kill or inhibit the growth of bacteria.
Levofloxacin is purely synthetic third-generation fluoroquinolones antibiotic. It is a flouroquinolone antibacterial agent which has a bactericidal activity against wide range of gram-positive and gram-negative bacteria.
Fluoroquinolone antibiotics have gained increased national attention due to safety concerns. A well-described and serious adverse event associated with receipt of fluoroquinolones is tendinitis and tendon rupture.
The current study is carried out to investigate the protective effect of curcumin, glucosamine hydrochloride and vitamin C on adverse effects of levofloxacin on serum levels of Ca, Ph, ALP activity, antioxidant/oxidant status, haema¬tological studies as well as histopathological changes in tendons, joints, ligaments and cartilages of immature albino rats.
Fifty immature albino rats weighing 70-90 g were allocated into five equal groups each of ten rats as follow:-
The 1st group(control) Rats received saline solution.
The 2nd group(levofloxacin) Rats received 10mg/kg body weight of levofloxacin once daily intraperitonial for 14 consecutive days.