الفهرس | Only 14 pages are availabe for public view |
Abstract The extensive use of FNT can lead to deleterious consequences in non-target organisms and NAC possess protective abilities against various toxic compounds, we hypothesized that NAC could restore the alterations induced by FNT poisoning. Therefore, this study has two main objectives: evaluating the hepatotoxic, nephrotoxic and neurotoxic effects of FNT and the possible ameliorative impact of NAC on FNT-induced toxicity in rats. This was accomplished via evaluation of biochemical parameters, oxidant/antioxidant status, pro-inflammatory cytokines, changes in the gene expression of xenobiotic-metabolizing enzymes (CYP1A1 and GSTA4-4) and seeking a possible link with histopatho¬logical changes in the target tissues. For this purpose, thirty-two adult male albino rats were randomly allocated into four equal groups as follow: group I, Control group, received 1ml distilled water orally once daily for 28 days. group II, NAC treated group (NAC), received N-acetylcysteine powder (200mg/ kg b.wt.) for 28 days. group III, FNT-intoxicated group (FNT), administered fenitrothion (10 mg/ kg b.wt.) for 28 days. |