الفهرس 
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Abstract
The fundamental goal of the present study is to evaluate the role of natural products of thymoquinone and royal jelly in management of oxidative stress and inflammatory insults characteristic for hepatitis in experimental rat model. The current study was conducted from adult female swiss albino rats weighting 200±20 g. The animals were classified into seven main groups (10 rats/group) as follows: group (I): Normal healthy animals served as negative control group. group (II): (Fluvastatin positive control group) Hepatitis rats were induced by fluvastatin in a dose 75 mg/kg b.wt. which experimentally tested, orally for 10 days that mimic to viral hepatitis (Cokca et al. 2005). group (III): (F+TQ) group. Hepatitis induced rats by Fluvastatin were treated with thymoquinone in a dose (20 mg/kg b.w) (Lebda et al. 2011) orally by intragastric gavage daily for 20 days. group (IV): ( (F+PG) group. Hepatitis induced rats by Fluvastatin were treated with aqueous suspension of pollen grains in a dose (400 mg/kg bw) (Yildiz et al. 2013) orally by intragastric gavage daily for 20 days. group (V): ((F+TQ+PG) group). Hepatitis induced rats were treated with combination of thymoquinone (20 mg/kg) and pollen grains (400 mg/kg b.w) orally by intragastric tube daily for 20 days. group (VI): (S) group. Normal healthy rats were given solokap 5.2 g/kg b.wt orally by intragastric tube daily for 20 days. group 7 :(F+S) group. Hepatitis induced rats were treated with solokap 5.2 g/kg b.wt as reference drug orally by intragastric tube daily for 20 days. Summary & Conclusion - 150 - Rats were received F for first 10 days only while received thymoquinone, pollen grains and solokap for all 20 days to improve its therapeutic effect. At the end of the experimental period, blood samples were collected after 12 hours fasting using the orbital sinus technique, under light anesthesia by diethyl ether, according to the method of(20) Van Herck et al. (2001). Each blood sample was left to clot in clean dry test tubes, and then centrifuged at 1800 xg for 10 min to obtain serum. After blood collection, the rats were euthanized and the whole liver tissues of each animal was collected and the first portion was homogenized immediately. The second portion of each brain was fixed in formalin buffer (10%) for histological investigation of all studied groups.