الفهرس 
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Abstract
The pancreas is an important digestive organ located in the upper abdomen. The pancreas has exocrine and endocrine functions. Many cysts can originate in the pancreas. Some of them can be precancerous. These cysts can be classified according to morphology, constituent or malignant tendency.
The common pancreatic cysts types are pseudocysts, serous cystadenoma, intraductal papillary mucinous neoplasia, and mucinous cystic neoplasm.
Current treatment recommendations based upon the recently published International Consensus Guidelines dictate a different treatment algorithm for different pancreatic cystic lesions that is why it is important to differentiate between them.
Prostaglandin E2 is naturally occurring prostaglandin that participates in a wide range of body functions. It is released by blood vessel walls in response to infection or inflammation of any part of the body including the pancreas.
According to these data, prostaglandin E2 studied as a marker for differentiation between different types of pancreatic cysts and grading of IPMN dysplasia on 40 patients from Cairo university hospital.
We concluded that there was significant differences in PGE2 level between true and inflammatory cysts (p value =0.001). Its cutoff value was 302.69 with accuracy 86.7 %.
Also PGE2 levels have significant statistically differences between MCN, ScN & ACC (p value =0.004, 0.036 respectively) and between SCN, ScN &ACC (p value = <0.001, 0.006 respectively), the best cutoff value for PGE2 differentiating MCN &ScN was 302.69 pg/ml This is considered an excellent test with accuracy value of 91.7 % while it is for differentiation between SCN&ScN was 302.69. This is considered an excellent test with accuracy value of 100.0 %.
We also concluded that PGE2 has statistically non-significant differences between IPMN &MCN (p value =0.519).
The study showed that PGE2 has statistically non-significant differences between different grades of IPMN dysplasia (p value = 0.615).
It also showed that PGE2 had statistically non-significant differences for prediction of recurrence and recurrent pancreatitis (p value =0.274, 0.186 respectively).