الفهرس 
INRODUCTIONOnly 14 pages are availabe for public view
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Abstract
In the light of the continuously expanding poultry industry and its growing significance for global food production, control of coccidiosis became a must. Prophylaxis has been the preferred method for the control of coccidiosis in poultry because once clinical signs become apparent treatments are often too late to prevent the pathological consequences of infection.
Whereas diclazuril and amprolium are among the most commonly administered anticoccidial agents in veterinary medicine for combating avian coccidiosis, their continuous administration may lead to their accumulation in poultry’s tissues and consequently may possess potential hazards on human consumers’ health.
Hence, the only way to guarantee food safety is to test foodstuffs for the presence of drug residues .Due to the global use of anticoccidials, the development and validation of useful methods for determination of these compounds is a concern for food safety concerning authorities.
The concept of coccidiosis prevention in chickens was achieved in this trial by oral administration of diclazuril (0.3 mg/kg body weight) and amprolium (100 mg/kg body weight) to apparently healthy chicks at different ages. A total of 300 broiler chicks of one day old were used in this study. They were divided into 6 equal treated groups each of 45 chicks and control group comprise 30 chicks for method validation tests.
group I: Control group for spiking and method validation test.
group II: Chicks in this group were orally gavage diclazuril at a dose rate of 0.3 mg/kg bodyweight once daily for 3 successive days only at age of 15th day old.