الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Monosodium glutamate (MSG) is a white crystalline powder and appears like common salt. Due to its flavor enhancing effect, it has been widely used as a food additive in human and livestock diets. Glutamate is the main excitatory neurotransmitter in the body and categorized as an excite-toxin. Several studies have reported the adverse effects of Monosodium glutamate on body systems mainly due to oxidative stress. Antioxidant effects of vitamin C have been demonstrated in many experiments in vitro.
In this study, 100 adult albino rats randomly allocated into 4 groups; group A – control rats treated with distilled water; group B– Vit.C treated rats (200 mg/kg BW per day in distilled water); group C– MSG–treated rats (60 mg/Kg BW per day in distilled water); group D –MSG plus Vit.C-treated rats; Daily for successive 90 days; then all animals were scarified. Blood was collected for biochemical analysis. Glutathione (GSH) and malondialdehyde (MDA) levels were determined in the brain, liver, and kidney homogenates. Histopathological examination of the brain, liver, kidneys and adrenal gland was conducted through hematoxylin-eosin staining.
Our data showed that MSG and Vit.C co-treatment decreased brain, liver and Kidneys MDA levels, Urea, uric acid, Cholesterol, triglycerides, LDL levels that were increased in MSG group. HDL, absolute organ weights and GSH content in the brain, Liver and Kidneys were increased in D group comparing to C group. Vit C had no improving effects on ALT, AST and Creatinine levels. Brain, Liver, kidneys, and adrenals histological sections show degeneration, atrophy, fibrosis and chronic inflammatory cells. Vit.C supplement group showed a degree of improvement in brain, Kidneys and adrenals but increase destructive effect of MSG on liver.