الفهرس 
Pathophysiology of PONVOnly 14 pages are availabe for public view
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Abstract
Summary
Laparoscopic surgeries are the preferred surgical procedures these
days. These have considerably decreased the surgical mortality, but the
incidence of PONV remains high. These factors reduce the quality of life of
the patients and interfere with continuation of curative therapy, hence the
need for prophylactic antiemetics. In addition to patient dissatisfaction,
PONV may have other adverse consequences such as delayed recovery,
unexpected extended hospital stay, and delayed return to work.
Granisetron is a highly selective and potent 5-HT3 receptor
antagonist. It acts specifically at 5-HT3 receptors on the vagal afferent
nerves of the gut, producing irreversible block of the 5-HT3 receptors, and
may account for the long duration of this drug.
Palonosetron is a unique 5-HT3 receptor antagonist having a greater
binding affinity and longer half-life than other 5-HT3 antagonists such as
ondansetron. Recent receptor binding studies suggest that it is further
differentiated from other 5-HT3 receptor antagonists by interacting with
5-HT3 receptors in an allosteric, positively cooperative manner at sites
different from those that bind with ondansetron and granisetron. This sort of
receptor interaction may be associated with long-lasting effects on receptor
ligand binding and functional responses to serotonin.
The aim of this study is to evaluate the safety and the efficacy of
Palonosetron versus Granisetron for prevention of the postoperative nausea
and vomiting following laparoscopic gynecologic surgery.
This prospective randomized double-blinded study was carried out
in Tanta University Hospital, obstetrics and gynecology department over 60