الفهرس | Only 14 pages are availabe for public view |
Abstract Summary Surface epithelial ovarian cancers are regarded as the most challenging -to -deal -with causes of death among gynecological malignancies due to late stages at time of diagnosis and therapy resistance. Based on these concepts, newer strategies that may be effective in predicting survival and enhancing sensitivity to chemotherapy are continuously assessed and subjected to experimental trials. Surface epithelial ovarian tumors exhibit various pathological features and are classified according to the classification of World Health Organization 2014 into three broad categories based on tumor behavior; benign, borderline and malignant, with each category encompasses various histopathological subtypes. TRAP1 is a member of the Heat Shock Protein 90 (HSP90) family, which is mainly located in the mitochondria. TRAP-1 mRNA of 2225 nucleotides is transcribed from a single locus on chromosome 16p13 in humans. It plays different roles in carcinogenesis by maintaining energy homeostasis in transformed cells and preventing apoptosis which contribute to tumor cell survival under conditions of stress normally encountered during neoplastic growth. The Tp53 tumor suppressor gene is located on the short arm of chromosome 17. This gene mutationis the most common genetic event in human malignancy, including ovarian carcinomas. The p53 protein is suspected to various types of aberration such as deletion |