الفهرس 
PainOnly 14 pages are availabe for public view
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Abstract
Summary
Postoperative pain of laparoscopic cholecystectomy (LC) is less
intense than that of open cholecystectomy, and LC is typically performed as
ambulatory surgery, although the approach is not pain-free. Especially, some
patients complain of severe pain during the first 24 hours after LC.
The origin of pain after LC is complicated. Thus, a combination of
inflammatory, incisional somatic, and visceral components, multimodal
analgesic regimens and various treatments are suggested, which include
opioids, NSAIDs, dexamethasone, injection of local anesthetics into the
surgical wound, and removal of residual carbon dioxide.
Intravenous lidocaine has analgesic, anti-hyperalgesic, and antiinflammatory
effects due to sodium channel blockade and inhibition of Nmethyl-
D-aspartate (NMDA) receptors. Intravenous lidocaine provides pain
relief after open abdominal and laparoscopic surgeries including LC.
Dexmedetomidine is a specific α2-adrenergic receptor agonist that
has anti-nociceptive and sedative properties. Intravenous dexmedetomidine
has a role as postoperative analgesia, which leads to the reduced requirement
for opioids.
The aim of this study is to evaluate the effect of intravenous infusion
of Lidocaine versus Dexmedetomidine on consumption of analgesics during
laparoscopic cholecystectomy.
This triple blind randomized controlled study was carried out on 60
patients aged 20 – 60 years old, both sex, ASA physical status I or II
scheduled for elective laparoscopic cholecystectomy under general
anesthesia.