الفهرس | Only 14 pages are availabe for public view |
Abstract New pyrazole, oxazole and pyridine derivatives bearing naphthalene, furan and dimethylaminophenyl moieties have been prepared by condensing 3-(furan-2-yl)-1-(naphthalen-2- yl)prop-2-en-1-one 1 and /or and 3-(3-(dimethyl amino) phenyl)-1-(naphthalen-2-yl) prop-2-en-1-one 2 with different nitrogen and carbon nucleophiles such as hydrazine, hydroxylamine, cyclohexanone, cyclopentanone, ethyl cyanoacetate and malononitrile, respectively. Elemental and spectroscopic evidences characterized all the newly synthesized compounds. All of the newly synthesized compounds were tested in vitro for their anti-proliferative activities against HePG-2 and MCF-7 cell lines. Keywords: chalcone, pyrimidine, cytotoxic activity. |