الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 147 |  |  |
| | | from | 147 | | |
Abstract
Type 1 and type 2 diabetes can have severe complications such as diabetic nephropathy. Diabetic nephropathy is considered one of the most common causes of chronic kidney disease.
Much research effort is being put into how to diagnose diabetic nephropathy in diabetic patients. A large number of biomarker studies were published on markers in plasma or urine, either with the aim to distinguish patients with or without diabetic nephropathy, or with the aim to expect renal outcome in those patients with diabetic nephropathy .
This cross-sectional observational study recruited sixty patients with longstanding T2DM and twenty healthy control persons . Patients with T2DM were further stratified based on their urine albumin–creatinine ratio (UACR) into three groups ; normoalbuminuric , microalbuminuric and macroalbumuinuric . Serum concentrations of ZAG were determined using an enzyme-linked immunosorbent assay.
Serum Adipokine zinc alpha-2-glycoprotein (ZAG) concentration was directly correlated in T2DM patients. Serum levels of ZAG were significantly higher in comparing each subcategory of type II DM with healthy control persons wih no significant difference between ZAG levels between the three subgroups of T2DM and no detected correlation with BMI, blood pressure, glucose serum levels, cholesterol, HDL, serum electrolytes, creatinine or e-GFR.
These preliminary findings suggest that ZAG may be a potentially useful biomarker for early diagnosis of diabetic nephropathy in T2DM patients.