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Abstract This study was performed to determine the efficacy of platelet rich plasma (PRP) injection versus extracorporeal shock-wave therapy in treatment of plantar fasciitis. This study involved 60 patients with planter fasciitis divided into 2 groups. group I received single PRP injection. group II received 3 sessions of shock wave therapy (24 females and 6males in each group)with mean age of 41.8±9.83 months in group I and 37.3±8.1 in group II, the disease duration was 8.73±3.09 months in group I and 9.73±3.55in group II. Patients were diagnosed as planter fasciitis according to the point of maximal tenderness on clinical examination over the medial tubercle of the calcaneus plus sonographic features, increased thickness of the plantar fascia more than 4 mm at baseline and hypoechoic fascia. All patients were subjected to the following: *Full history taking, *Full detailed clinical examination. * Laboratory assessment. *Assessment of pain levelby visual analogue scale (VAS). *Assessment of pain and function by American orthopedic foot and ankle society (AOFAS)ankle-hindfoot scale. *Measurement of planter fascia thicknessand echogenicity by ultrasonography. The results showed the following: • There was no significant difference among studied groups regarding age, gender, affected foot side, disease duration, body mass index, baseline VAS & AOFAS ankle-hindfoot scale and ultrasound findings of planter fascia. • The percentage of patients with calcaneal spur in lateral foot radiograph was 40% in group I and 53,3% in group II. • There was a highly significant difference regarding VAS in both groups as it was lower at one month after injection and three months than before injection & P value<0.001. • There was a highly significant difference in regarding AOFAS ankle-hindfoot scale in both groups as it was higher (improved) at one month after injection and three months than before injection & P value <0.001. • There was a highly significant difference regarding planter fascia thickness in both groups as it decreased at one month after injection and three months than before injection P value <0.001. • There was non significant difference among studied groups regarding VAS before and after treatment. • There was non significant difference among studied groups regarding AOFAS ankle-hindfoot scale before treatment and three months after treatment but there was a significant difference one month after treatment as it was higher in group II than group I . • There was a highly significant difference among studied groups regarding planter fascia thickness three months after treatment as it was lower in group I than group II P value <0.001. • There was a highly significant difference among studied groups regarding planter fascia echogenicity at 1-months after treatment as became better in group I (73,3%) with normal echogenicity than group II that 40% became with normal echogenicity. • There was a significant difference among studied groups in patients with calcaneal spur regarding VAS at 1-months after treatment as became better in group II (5.62±1.36) than group I that was (6.83±1.11). • There was a highly significant difference among studied groups in patients with calcaneal spur regarding AOFAS ankle-hindfoot scale at 1-months after treatment as became higher in group II (77.8±4.66) than group I that was (68.6±9.13). |