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Abstract The present study aimed to investigate the type and degree of water pollution in Lake Temsah. Then, studying the effect of most recorded heavy metals on fish and role of garlic in improving the health status of exposed Red tilapia. The results during the field survey revealed higher level of lead followed by cupper then iron with no cadmium record. A total number of 165 Red tilapia Fish was equally distributed into five groups each with a triplicate of 11 fish. Lead acetate was added to tanks water of all groups of experiment except the control group and garlic was added and used as a treatment to selected groups. The groups exposed to Lead Acetate only revealed decrease in the RBCs, Hb%, HCT with increase in MCV and MCH and MCHC in the first 3rd and 6th weeks of the experiment. This in addition to, leukocytopenia, neutrophilia, lymphopenia with elevation in Serum Creatinine, ALT, AST in comparison with control group. When Garlic added during the experiment, an increase in the survival and significant increase in growth and weight-gain were seen in all treated groups beside significant improvement in the blood parameters and blood indices. Its concluded that, Garlic (at dose 0.25 g/ kg) eliminate partial heavy metals from the fish body, which in turn improved the growth and immunity of Red tilapia fish. Key words: Heavy metals, Garlic, Red tilapia, Serum Biochemistry, Hematology, Histopathology. |