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Abstract SUMMARY Unexplained infertility refers to the absence of a definable cause for a couple’s failure to achieve pregnancy after 12months of attempting conception despite a through evaluation, or after six months in women 35 and older, it approximately 15% to 30% of infertile couples will be diagnosed with unexplained infertility after their diagnostic workup. Receptivity now appears to be the bottleneck of the embryo implantation. Inadequate uterine receptivity is responsible for approximately two-third of these failures Endometrial scratching was defined as a scraping of the endometrium to obtain tissue for histological evaluation; however, this intervention has been suggested to boost embryo implantation following recurrent implantation failure after IVF. Many investigators suggested that endometrial scratching could have a favorable endometrial healing effect on the implantation process, which may trigger the release of many biochemical inflammatory mediators and cytokines involved in the enhancement of implantation. The aim of this study was to evaluate the effect of endometrial scratching on the cumulative pregnancy rate in couples with unexplained infertility. In this study, endometrial scratching was in women with natural cycle, and was carried out on selected 60 couples who had experienced unexplained infertility for at least one and half years were randomly allocated in two groups: group A (Study group): comprised 30 women underwent endometrial scratching in the posterior uterine wall at the preovulatory days of the. |