الفهرس 
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Abstract
This study aimed to evaluate the role of Th17 and IL23 in the immune pathogenesis of hypertension.
This study was carried out in the Internal Medicine Department, faculty of medicine, Ain Shams university hospital during the period from November 2016 to December 2017.
In this study we performed full history taking and examination, we also performed complete blood count, liver function tests, kidney function tests, estimation of IL23 level in plasma by ELISA and estimation of Th17 percentage & absolute count in peripheral blood by Flowcytometry.
Forty five adult individual were recruited in the study and were further divided into three groups according to the symptoms of blood pressure as follow:
group A: 15 patients with acute increase of blood pressure.
group B: 15 patients without acute increase of blood pressure.
group C: We also included 15 healthy volunteers with normal blood pressure as control.
According to results of our study we found that mean of IL17/CD4% was higher in group A, followed by group B then group C.
Also mean of IL23/CD4% was higher in group A, followed by group B then group C, all these differences was high significant
However CD4 was higher in group C followed by group A then group B with non significant difference.
Additionally mean of IL17-23/CD4% was higher in group A, followed by group B then group C.
We found also that mean of IL23-E was higher in group A, followed by group B then group C, all these differences was high significant.
Regarding correlation between IL17/CD4% & IL23/CD4%, we found that IL17/CD4% is highly significant correlated with IL23/CD4% in both groups A and B and significant correlated in group C.
We also found that IL17/CD4% highly significant correlated with each SBP, DBP and HDL, it also significant correlated with each LDL, TG and SGPT. On the other hand it was non significant correlated with each TC, HB, SGOT, CD4, Urea, Creatinine and age of the subjects.
We also found that IL23/CD4% highly significant correlated with each SBP, DBP and HDL, it also significant correlated with each TG, SGOT and SGPT. On the other hand it non significant correlated with each TC, LDL, HB, CD4, Urea, Creatinine and age of the subjects.
Regarding laboratory investigations (urea, creatinine, S.GPT, S.GOT, HBG) there was non significant difference between three groups.
By studying demographic data (i.e. age and gender) of each group we found no significant differences.
by studying Systolic and diastolic blood pressure of studied populations, we found that mean of SBP in our study groups was the highest in group A followed by group B followed by group C with high significant difference, on the other hand, mean of DBP in group A was the highest followed by group B followed by group with high significant difference.
In conclusion:
We conclude that that IL-23 and Th17 cells may be involved in the pathogenesis of acute blood pressure increase in the patients with hypertension. Understanding inflammatory character might be of great importance in prevention and treatment of acute blood pressure increase in hypertensive patients.