الفهرس 
Definition and Epidemiology:
Diabetic kidney disease (DKD)Only 14 pages are availabe for public view
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Abstract
Summary & Conclusion
Podocalyxin is an integral membrane protein coating the secondary
foot processes of kidney podocytes maintaining their structural integrity. It
tends to increase in urine of patients with type 2 diabetes mellitus indicating
defected glomerular filtration barrier. This occurs before the development of
albuminuria.
We aimed in this present work to study the role of podocyte associated
protein in early detection of diabetic nephropathy in patients with type 2
diabetes mellitus. This cross-sectional study was conducted on 90 patients
with type 2 DM and 10 healthy individuals as control. Following quantitative
measurement of urine samples with ELISA to detect podocalyxin. The
diabetic patients were divided into three groups according to their
albumin/creatinine ratio (30 patients with normoalbuminuria, 30 patients
with microalbuminuria and 30 patients with macroalbuminuria).
This study was carried on patients from internal ward and outpatient
clinic, Internal Medicine Department, Tanta University Hospital. All the
patients and controls were subjected to full history taking, complete clinical
examination and laboratory investigations (Complete urine analysis, serum
creatinine, blood urea, ACR ratio and measurement of podocyte- associated
protein in urine by ELISA).
Patients with known kidney disease whatever the cause, uncontrolled
hypertension, fever, urinary tract infection (UTI), congestive heart failure,
severely uncontrolled DM (HbA1c > 9%), Menstruating and pregnant
females were excluded from this study.
Chapter VII Summary & Conclusion
80
Our results showed that there was statistically nonsignificant change
between all studied groups as regard to age and sex.
Systolic blood pressure (SBP) showed nonsignificant increase in group I
when compared with group II or group IV (P value > 0.05). group II revealed
significant increase of SBP in comparison with group IV while it showed
nonsignificant increase when compared with group III. There was statistically
highly significant increase of SBP in group III in comparison to group I & group IV
(P value < 0.05).
Diastolic blood pressure (DBP) revealed nonsignificant increase in group I
when compared group IV (P value > 0.05). group II showed nonsignificant
increase when compared with group III while it showed highly significant increase
of DBP when compared with group I and group IV (P value < 0.05). There was
statistically highly significant increase of DBP in group III in comparison to group
IV.
Duration of diabetes was highly significant longer in group III compared to
group I and II (P value < 0.05).
Fasting blood glucose (FBG) was non-significantly increased in group I
compared to group II while it showed highly significant increase of FBG when
compared with group IV. Also, there was highly significant increase in group II
compared with group IV. Also, FBG showed highly significant increase in group III
when compared with groups I, II and IV (P value < 0.05).
Post prandial blood glucose (PPBG) was significantly increased in group I
when compared with group IV. Also, there was significant increase of PPBG in
group II compared to group I and highly significant increase when compared with
group IV (P value < 0.05). Also, PPBG showed highly significant increase in group