الفهرس 
TitleOnly 14 pages are availabe for public view
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Abstract
Ionizing radiation is utilized in radiography, fluoroscopy, and
angiography and computed tomography (CT) besides nuclear medicine
examinations. Biological effects of ionizing radiation (IR) are induced by two
processes: direct damaging of deoxyribonucleic acid (DNA) or indirect by
generating free radicals.
Free radicals are defined as molecules or fragments of molecules
containing one or more unpaired electrons. They are highly reactive species
capable of damaging carbohydrates, lipids, proteins and/or nucleic acids, and
of causing loss of molecular functions.
Oxidative stress (OS) occurs when the production of free radicals (FRs)
exceeds the capacity of antioxidant defenses. Antioxidants are thought to
protect the body against the destructive effects of free radicals by neutralize
free radicals, so there is a need to develop an effective and non-toxic
radioprotector. These compounds are often antioxidants.
N Acetyl Cysteine (NAC), a well-known thiol-containing antioxidant,
Additionally, NAC is a potent free radical scavenger as a result of its
nucleophilic reactions with ROS.
The aim of the present study was to assess the biological damage of
ionizing radiation in medical radiation workers before and after using
radioprotector by measuring advanced oxidation protein products (AOPPs)
that are reliable markers of the degree of protein damage in oxidative stress,
Reduced glutathione (GSH) that is the major intracellular antioxidant in the
body and Malondialdehyde (MDA) is commonly used as a marker of lipid
peroxidation.
Summary
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This study was included 45 individuals divided into two groups.25
radiation workers were take Acetyl Cysteine effervescent 600 mg as a
radioprotector, twice a day for two months and 20 healthy volunteers.
We detected MDA in plasma sample of medical radiation workers by
spectrophometer at absorbance 534 nm,while AOPP was determined by
ELIZA in plasma samples also.GSH was detected in fresh erythrocytes
samples by spectrophometer at absorbance 405 nm.
In our study, we observed that medical field workers exposed to low
dose of ionizing radiation, the level of GSH decreased and the level of both
MDA and AOPP increased compared to normal state.
We found that after administration of Acetyl Cysteine effervescent 600
mg, twice a day for two months, increased the level of reduced glutathione
and decreased Malondialdehyde (MDA) levels and advanced protein
oxidation products (AOPP) concentration.