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Abstract This work is composed of three main chapters. The first chapter: - introduction In this chapter, a literature survey was carried out and included the following of items:- a) Introduction about importance of oximes and schiff bases. b) Importance of oximes and modes of bonding of oxime in metal complexes. c) Defintion, nomenclature and preparation of oximes and schiff bases. d) Importance of oximes and schiff bases and their metal complexes in the following fields of applications:- 1- Biological application: -Antitumor, anti-mycobacterial and antimicrobial activity. 2- Pharmaceutical application: -Anti-inflammatory activity, hydrazones in treatment of iron overload diseases, antimalarial, anti-trypanosomal and anti- convulsant. 3- Catalytic applications:-In many fields such as some polymerization processes and some chemichal reactions. 4- Analytical applications:-Such as separation and determination of traces of metals and determination of some species in pharmaceutical formulations. - Review of literature on, oximes and schiff bases. The second chapter: Experimental In this chapter, the methods used for the preparation of new oxime ligand (H4L), (1) and (H6L), (12) and preparation of their metal complexes for copper(II), nickel(II), cobalt(II), manganese(II), zinc(II), mercury(II) and iron(III). The techniques used for characterization of new ligand and its complexes were also described which included: elemental, thermal analyses, infrared spectra, proton magnetic resonance (1H-NMR), mass spectra, electronic absorption spectra (UV-VIS), electron spin resonance (ESR), magnetic also described biological activity of the oxime ligand and its metal complexes and determine the invitro cytotoxicity properties against hepatocellur carcinoma The third chapter:- Results and discussion The analytical and spectral studies showed the structural and spectroscopic properties revealed that the ligand(H4L), (1) and (H6L), (12) (adopted a tridentate fashion; on the other hand the metal complexes adopted a tetragonal distorted octahedral geometry around metal ions. All the complexes are non-electrolytic in nature as suggested by molar conductance measurements. The ligands coordinated to the central metal ion through a phenolic OH, one-imine nitrogen, one oximenitrogen atoms forming five-membered rings including the metal ions. The biological activity of the ligands and their metal complees were assessed against hepatocellur carcinoma .Results showed that by the study the cytotoxicity of the the ligand and its metal it was found that, ligand (1)Zn(II) complex (13) and Cd (15) appeared to be much cytotoxic (IC50 = 8.03,3.01 and 6.69 μg/ml respectively) against the cell lines of HepG-2 The toxicity of both ligand and metal complexes was found to be concentration dependent, the cell viability decreased with increasing the concentration.of.complexes. |