الفهرس | Only 14 pages are availabe for public view |
Abstract This work is composed of three main chapters. The first chapter: - introduction In this chapter, a literature survey was carried out and included the following of items:- a) Introduction about importance of oximes and schiff bases. b) Importance of oximes and modes of bonding of oxime in metal complexes. c) Defintion, nomenclature and preparation of oximes and schiff bases. d) Importance of oximes and schiff bases and their metal complexes in the following fields of applications:- 1- Biological application: -Antitumor, anti-mycobacterial and antimicrobial activity. 2- Pharmaceutical application: -Anti-inflammatory activity, hydrazones in treatment of iron overload diseases, antimalarial, anti-trypanosomal and anti- convulsant. 3- Catalytic applications:-In many fields such as some polymerization processes and some chemichal reactions. 4- Analytical applications:-Such as separation and determination of traces of metals and determination of some species in pharmaceutical formulations. - Review of literature on, oximes and schiff bases. The second chapter: Experimental In this chapter, the methods used for the preparation of new hydrazon oxime ligands (H2L)(1),(18) and preparation of their metal complexes for copper(II), nickel(II), cobalt(II), manganese(II), zinc(II) and iron(III). The techniques used for characterization of new ligands and its complexes were also (UV-VIS), electron spin resonance (ESR), magnetic also described which included: elemental, thermal analyses, infrared spectra, proton magnetic resonance (1H-NMR), mass spectra, electronic absorption spectra described biological activity of the oxime ligand and its metal complexes and determine the invitro cytotoxicity properties against human liver HEP-G2 cancer cell lines. The third chapter:- Results and discussion The analytical and spectral studies showed that the ligands behaves as monobasic tetradentate ligands. |