الفهرس | Only 14 pages are availabe for public view |
Abstract Summary Antipsychotic drugs are used mainly for treatment of schizophrenia and other psychiatric disorders as delusional disorder and bipolar disorder. These drugs are classified as first-generation (typical or conventional) antipsychotics and second-generation antipsychotics (atypical antipsychotics). Because of side effects associated with first generation especially extrapyramidal side effects, second generation antipsychotics were introduced in 1990. The Second generation has a lower risk to cause EPS as acute dystonia, akathisia, and tardive dyskinesia compared with first generation but associated with more risk of cardiac and metabolic abnormalities; weight gain, hyperlipidemia and glucose intolerance. These properties are due to their difference in receptor profiles but D2 receptor antagonism in the brain is still considered the primary common pharmacodynamic target for psychotropic drugs. Additionally, most cases of accidental or intentional antipsychotic poisoning will remain asymptomatic or develop only mild to moderate toxicity. Therefore, death after antipsychotic intoxication is a rare complication especially if treatment is initiated in proper time. Clinical manifestations of antipsychotic toxicity are CNS depression, miosis or mydriasis, orthostatic hypotension, cardiac conduction disturbances, atrial and ventricular dysrhythmias, anticholinergic manifestations and uncommonly seizures. Hence, the aim of this work was to assess the pattern and prognosis of cases with acute antipsychotic poisoning admitted to Tanta University Poison Control Unit. Summary 118 The present study was conducted on cases with antipsychotic overdose admitted to Tanta University Poison Control unit throughout the period |