الفهرس | Only 14 pages are availabe for public view |
Abstract Introduction: Obesity has reached epidemic proportions in many countries around the world. One mechanism by which obesity may contribute to the pathogenesis of T2DM is that the increased flux of FFAs from lipolysis in visceral adipose tissue causes insulin resistance and impairs pancreatic β-cell function. Tea is one of the most popular beverages consumed worldwide. Tea, from the plant Camellia sinensis, is consumed in different parts of the world as green, black, or oolong tea. Catechins are the main compounds in green tea reduce the risk of a variety of diseases. Green tea catechins affect lipid metabolism by different pathways and prevent the appearance of atherosclerotic plaque green tea intake decreases the absorption of triglycerides and cholesterol and these findings are in accordance with the fact that fat excretion increases and could have a beneficial effect against lipid and glucose metabolism disorders implicated in years, interest has increased in using natural products for pharmacological purposes, as a form of complementary or replacement therapy as Inulin, a group of dietary fibers, is reported to improve the metabolic disorders. Inulin decreased serum triglycerides and abdominal fat deposition and may have unique metabolic effects that are of particular benefit to people at risk of diabetes. Material and Methods: The study was conducted on 08 male albino rats divided into two main groups, the first main group 40 rats were infected with Diabetes were divided into 8 sub-groups fed on basal diet plus (15 ml green tea + 0.2 or0.5 mg catechin, 15ml green tea + 14 or 18 gm inulin or its combination). Likewise, has fueled second major group (infected with obesity and feed high fat diet). In first main group diabetic rats results revealed that, all treated rats resulted in significant increase (P<0.01) of feed intake, body weight gain %, Adiponectin and weight of organs% than positive control group, while total Cholesterol, triglyceride, LDL-c , VLDL-c , HDL\LDL ratio ,Leptin and blood glucose was decreased. In second main group Obese Rats results revealed that, all treated rats with15 ml enriched with catechin and inulin resulted in significant decrease (P<0.01) of feed intake, body weight gain %, Leptin total Cholesterol, triglyceride, LDL-c, VLDL-c, HDL\LDL ratio and blood glucose than positive control group (Untreated fed on high fat diet) while Adiponectin and HDL-c was increased while There were no significant differences Relative weight of organs%. In conclusion, green tea catechin and inulin appears to improve not only hyperglycemia but also dyslipidemia. |