الفهرس | Only 14 pages are availabe for public view |
Abstract The present thesis comprises the following chapters: Chapter I (Introduction): An introductory part describing the chemistry of spiroimidazolidinediones , different approaches for its synthesis and aldose reductase inhibitors as targeted hypoglycemic agents.such as glibenclamide and repaglinide. Chapter II (Research Objectives): The synthetic routes for the preparation of target compounds were illustrated by 5 schemes. Chapter III (Theoretical Discussion): A theoretical discussion of synthetic pathways that were developed to obtain the final new compounds and their mechanisms, spectral data, biological results and molecular modeling. Chapter IV (Experimental): The present investigation involves the synthesis of 7 intermediates. In addition to, the synthesis and characterization of the following 22 compounds. Chapter V (Conclusion): A summary of the present study, conclusions and the future work. Chapter VI (References): A list of references which were used and their arrangement according to their order in the thesis. |