الفهرس | Only 14 pages are availabe for public view |
Abstract Salivary gland malignant tumors are extremely variable in comparison to other malignancy types, including about 24 different subtypes. Although radiotherapy is considered the most damaging treatment modality to salivary glands, other modalities result in gland atrophy and hypofunction. Last stem cell researches in the dental field have detected a diversity of adult stem cell sources in the oral and maxillofacial region. GMSCs exhibit clonogenicity, self-renewal and a multipotent differentiation capabilityity similar to that of BM-MSCs. MSCs in fibrin glue(as a scaffold) have more efficient immune-regulatory properties. In contrast, MSCs within fibrin glue hardly migrate. In this study, gingiva-derived mesenchymal stem cells with fibrin glue caused reconstruction of partially dissected submandibular salivary gland in rats. |