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العنوان
The Effect of Lyophilized Human Platelet Derived Growth Factors on Split-Thickness Skin Graft Take in the Treatment of Post Burn Raw Area: Matched Control Clinical Trial/
المؤلف
Botros,Rania Roshdi Faried
هيئة الاعداد
باحث / رانيا رشدي فريد بطرس
مشرف / سامي أحمد عبد الرحمن
مشرف / أحمد صبحي هويدي
تاريخ النشر
2018
عدد الصفحات
105.p:
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
جراحة
تاريخ الإجازة
7/3/2018
مكان الإجازة
جامعة عين شمس - كلية الطب - General Surgery
الفهرس
Only 14 pages are availabe for public view

from 105

from 105

Abstract

The post burn raw area is considered the most common complication of the burn and its management is difficult especially with large total body surface area of the burn.
Skin graft is a good choice in treatment of the raw area and its take is difficult in almost burnt patient as the systemic effect of burn affect the graft take.
There are many factors that increase the graft take; systemic and local factors. Among these local factors is the PRP. Its application on the bed of the graft is approved in many studies to be helpful in graft take.
Although the discovery of the LPDGFs (lyophilized platelet derived growth factors) as a recombinant DNA, literature proved that using PRP is more potent in healing than the single growth factor as LPDGF.
LGF differs from the LPDGF in being have all the platelet growth factors but, in huge amount than in the PRP without the fibrinogen, so its use will not be restricted as PRP because it doesn’t have the fibrinogen.
LGF is a newly discovered custom made as it is prepared from the blood donation in vitro, we used this material in our study and proved it’s significant effect on graft take, decreasing the infection rate and pain scale and improve the scar.
LGF increased the 1st dressing graft take, decreased the infection rate, Pain from the graft and improved the quality of the scar, but made no difference neither the 2nd dressing graft take nor the instant adhesion of the graft to the bed.