الفهرس 
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Abstract
Physical exercise is suggested as a life style modification to
improve hypertension. The aim of the present work was to study the
impact of exercise training on some hemodynamics and inflammatory
mediators in hypertensive rats, and to investigate whether this effect is
reversible after detraining.
Experimental animals and groups:
Forty eight white male albino rats were used in this study. Rats
were classified into the following groups:
Group1: Normotensive group (n=24): rats of this main group were
equally divided into:
A- Sedentary normotensive (NS) group
B- Exercise-trained normotensive (N.Ext) group
C- Detrained normotensive (N.Det) group
group 2: Hypertensive group (n=24): rats of this main group were
equally divided into:
A- Sedentary hypertensive (HS) group
B- Exercise-trained hypertensive (H.Ext) group
C- Detrained hypertensive (H.Det) group
Method:
Hypertension was induced by subcutaneous injection of
deoxycorticosterone acetate (DOCA) in a dose of 50 mg/kg body
weight suspended in 0.3 ml olive oil, once weekly for 4 weeks and
drinking water with 1% NaCl. Rats in exercise-trained groups
practiced moderate intensity treadmill exercise for 6 weeks. Rats in
detrained groups practiced moderate intensity exercise for 4 weeks
and remained sedentary for 2 weeks.
After 6 weeks, in all of the previously mentioned groups, retroorbital
blood samples were collected for measuring serum levels of the
proinflammatory marker TNF-α, the anti-inflammatory marker IL-10,
the lipid peroxidation indicator MDA and the antioxidant activity
indicator TAC.
Then, systolic and diastolic ABP of each animal were measured
by invasive technique and MAP was calculated.
Lastly, rats were sacrificed and heart was excised for assessing
myocardial contractility and heart rate by Langendorff isolated
perfused heart technique.