الفهرس | Only 14 pages are availabe for public view |
Abstract Schizophrenia is a mental disorder characterized by abnormal social behavior and failure to understand what is real. Its symptoms typically occurs in young adulthood with approximately 1% of the world’s population affected. Schizophrenic patients treated with typical antipsychotics alone, atypical antipsychotic or combination therapy of antipsychotics. The use of antipsychotic medications entails a difficult trade-off between the benefit of alleviating psychotic symptoms and the risk of troubling, sometimes life-shortening adverse effects. Once patients are exposed to different drugs with anticholinergic, adrenergic or serotoninergic properties they can experience ocular adverse effects as a result of these properties The eye is supposed to be the second organ to manifest drug toxicity following liver. The ocular adverse effects of these drugs depending upon the idiosyncrasies, dosages and the interactions with specific mechanisms of the body organs. This study aimed to assess the possibility of occurrence of ocular toxic effects of antipsychotic drugs, evaluate intraocular pressure of chronic psychotic patients treated with antipsychotic medications, and relate ocular toxic effects in patients treated with a variety of antipsychotics to duration of treatment and to detect early ocular toxic effects for early intervention. The present study conducted on 100 chronic adult psychotic patients aged between 20-60 years out of them78% males and 22% females attending EL–Hadara University Hospital treated with antipsychotic drugs for a period more than six months. |