الفهرس | Only 14 pages are availabe for public view |
Abstract The current study aimed to investigate the effect of celecoxib, aspirin and -3polyunsaturated fatty acids (3- PUFAs) on seizure activity and neurodegeneration in pentylenetetrazole (PTZ) –kindled rats focusing on their effect on production of lipoxinA4 (LXA4)and expression of formyl peptide rdceptor-like1 (FPRL1) receptors.Preteratment with aspirin and 3- PUFAs reduced convulsive behavior exhibited by rats, level of LXA4 and the percent of degenerative cells in the brain compared to PTZ-kindled rats. |