الفهرس 
Anatomy of the BreastOnly 14 pages are availabe for public view
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Abstract
Breast cancer is most prevalent and is the leading cause of cancer related deaths among women worldwide.
The early and accurate diagnosis of breast cancer is crucial for successful treatment and to improve the quality of life. There are several imaging modalities for diagnosis of breast lesions. The commonest are mammography and ultrasonography. But In view of the limitations of mammography and other techniques, considerable interest is focused on breast MRI.
The sensitivity of breast MRI for the detection of cancer is the greatest of all imaging techniques and when the findings of conventional imaging are inconclusive. MRI can be used as a problem-solving modality, it is also better at identifying the true extent of cancer when multifocal disease or ductal carcinoma in situ is present. However its reported specificity is variable.
Recent developments in MR imaging technology have enabled the clinical application of DWI to the entire body, which has shown great promise for the detection and characterization of most tumor types.
Through imaging of alterations in the microscopic motion of water molecules, DWI can yield novel quantitative and qualitative information reflecting cellular changes that can provide unique insights into tumor cellularity.
With respect to breast DWI a potential role for the apparent diffusion coefficient (ADC), a quantitative measure that is directly proportional to the diffusion of water and inversely proportional to the tumor cellular density, has been reported to be useful for characterizing breast tumors and distinguishing malignant tissues from benign tissues.
So use of DWI as a diagnostic tool can increase the specificity of breast MR imaging in comparison to DCE-MRI alone and can reduce the number of false-positive results and associated unnecessary biopsies. In addition, DWI can be performed without significantly increasing examination time.
The current study evaluated the role of DWI and ADC values as an adjunct to contrast enhanced-MRI in assessment and differentiation of breast masses.
We conducted the study in Ain Shams University Hospitals. The study included 35 patients. Cases were referred from general surgery and oncology departments.
All patients underwent contrast enhanced-MRI, DWI and ADC values measurements with documentation of findings. Those findings were correlated with histopathological results and/or follow up.
We found that DWI and ADC measurement increased the specificity of the breast MRI in characterization of different breast lesions; this was independent on lesion size or type and also was of great help in differentiating between post-therapeutic changes from recurrent breast cancers.
In our study the sensitivity was 100% and the specificity was 86.67%.