الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
 |  | from | 182 |  |  |
| | | from | 182 | | |
Abstract
Idiopathic pulmonary fibrosis (IPF) is defined as a specific form of chronic, progressive fibrosing interstitial pneumonia of unknown cause, primarily occurring in older adults, limited to the lungs, and associated with the histopathologic and/or radiologic pattern of usual interstitial pneumonia (UIP).
IPF IS a fatal lung disease; the natural history is variable and unpredictable:
a. Most patients with IPF demonstrate a gradual worsening of lung function over years; a minority of patients remains stable or declines rapidly.
b. Some patients may experience episodes of acute respiratory worsening despite previous stability.
Health Related Quality of Life (HRQL) is a broad concept which can be defined as a patient’s general subjective perception of the effect of illness and intervention on physical, psychological and social aspects of daily life.
Two types of HRQL questionnaires are widely available: generic and disease-specific instruments.
The aim of the current study was to compare two questionnaires which measure the health-related quality of life of idiopathic pulmonary fibrosis patients which are Medical Outcomes Short Form 36 and Saint George’s Respiratory Questionnaire.
The current study was conducted on 30 IPF patients admitted to EL-Mahlla Chest Hospital in the period between January 2016 to December 2016.
After obtaining a written informed consent, they were subjected to demographic data acquisition, detailed history taking, thorough clinical examination, HRCT Chest Scan, ABG (PaO2, SaO2), PFTs (spirometry), 6MWD test .then they were asked to complete two questionnaires (Medical Outcomes Short Form 36 and Saint George’s Respiratory Questionnaire) to assess HRQL.
In this study, regarding demographic data, the age of the patients ranged from 39 to 65 with a mean± SD (52.80 ± 7.22)years , all of the patients were females and the body mass index ranged from 22-29 with a mean ± SD (26.24 ± 1.83).
In this study, regarding the spirometric results the patients presented on a restrictive pattern where FVC% of predicted of the patients ranged from (35.30 – 57.40) with a mean± SD (46.24 ± 6.41) ,the FEV1% of predicted ranged from(37.30 – 59.10) with a mean± SD( 47.89 ± 6.94).
FVC and FEV1% of predicted showed a highly significant negative correlation with all SGRQ domains (Symptoms, Activities, Impact and Total score) (p ≤ 0.001) and a statistically significant positive correlation with Physical function, Vitality, Social function and General health perception domains of SF-36 (p ≤ 0.05).
As regards dyspnea at rest in this study the Baseline Dyspnea Index results showed severe limitation (4.63 ± 1.30) and there was a highly significant positive correlation between lung function (FVC and FEV1 % of predicted) and all Baseline Dyspnea Index domains (p ≤ 0.001).
There was a statistically highly significant negative correlation between Baseline dyspnea index and all SGRQ domains (p ≤ 0.001), Baseline dyspnea
index showed a significant positive correlation with (physical function, vitality, general mental health and general health perception). (p ≤ 0.05).
As regards Exercise Capacity, six-minutes walk distance (6MWD), the patients showed an average impairment of exercise capacity. 6MWD ranging from (220.0 - 470.0) meters with a mean ± SD (376.67± 75.95) meter. There was a statistically significant positive correlation between exercise capacity (6MWD) and lung volumes (FVC and FEV1% of predicted), (p ≤ 0.05).
There was a highly significant negative correlation between 6MWD and all SGRQ domains (symptoms, activity, impact and total score) (p ≤ 0.001).and a significant positive correlation with SF-36 domains (physical function, vitality, general mental health, social function and general health perception) (p ≤ 0.05).
In this study there was a statistically highly significant positive correlation between exercise capacity (6MWD) and Baseline dyspnea index (BDI). (p≤ 0.001). There was also a significant negative correlation between symptoms and Impact domains of SGRQ with all SF-36 domains except role limitation and bodily pain and there was a significant negative correlation between activity domain of SGRQ with all SF-36 domains except role limitation, bodily pain and role limitation due to emotion.