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Abstract Introduction: The human intestinal microbiota is a complex and dynamic ecosystem with 300-500 different species of bacteria and plays an important role in maintaining host health since it is involved in nutrition, pathogenesis, and immunology .The gut microbiota of an individual is influenced by different dietary habits during life. The gut microbiota of children fed a modern western diet compared to a rural diet has been characterized, and the effect of dietary polyphenols on the human gut microbiota has been reported. Aim of the work: To detect relation between Fecal Calprotectin (FC) level and fecal bifidobacteria and lactobacillus levels in exclusively breastfed infants versus formula fed infants. Subjects and Methods: This was a case control study conducted on 50 infants divided into 2 groups, group A: exclusively breastfed infants, group B: formula fed infants (on standard formula). The participants were recruited from Ain-Shams university pediatrics hospital clinical nutrition clinic in the period between Februry 2016 and June 2016, Cairo, Egypt. Results: This case control study was conducted on 50 infants devided 29females(58%) and 21males(42%), born at a median gestational age of 39 weeks (range 37-41 weeks) with a median birth weight of 3 kg (range 2.8 – 4kg). They were divided into 2 groups, group A: exclusively breast fed infants (54%), group B: formula fed infants (on standard formula) (46%). Conclusion: Our study showed higher fecal lactobacillus (p=0.028), fecal bifidobacterium (p=0.043). and fecal calprotectin (p=0.000) levels in exclusively breast fed infants than in formula fed ones in the first 6 months of life. Recommendations: We encourage breastfeeding as best nutrition for children in the first six months. Further research for larger sample size is needed. We need to study more diverse microbiota in these infants and their effect on growth and inflamation. We encourage normal vaginal delivery. |